What is the mechanism of action of disulfiram?

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Prepare for the Dr. High Yield Psychiatry Test. Study with flashcards and multiple choice questions, each with hints and explanations. Ensure success in your exam!

Multiple Choice

What is the mechanism of action of disulfiram?

Explanation:
Disulfiram works by blocking aldehyde dehydrogenase, the enzyme that converts acetaldehyde into acetic acid during alcohol metabolism. When someone takes disulfiram and drinks alcohol, acetaldehyde rapidly accumulates because its breakdown is inhibited. This build-up triggers an unpleasant aversive reaction—flushing, rapid heartbeat, dizziness, nausea, headache—making drinking self-limiting. This creates a deterrent effect that supports abstinence in alcohol dependence. Clinically, it’s used as an aversive therapy, but patients must avoid all sources of alcohol (including mouthwash or certain medications) due to potential reactions, and liver safety must be monitored.

Disulfiram works by blocking aldehyde dehydrogenase, the enzyme that converts acetaldehyde into acetic acid during alcohol metabolism. When someone takes disulfiram and drinks alcohol, acetaldehyde rapidly accumulates because its breakdown is inhibited. This build-up triggers an unpleasant aversive reaction—flushing, rapid heartbeat, dizziness, nausea, headache—making drinking self-limiting. This creates a deterrent effect that supports abstinence in alcohol dependence. Clinically, it’s used as an aversive therapy, but patients must avoid all sources of alcohol (including mouthwash or certain medications) due to potential reactions, and liver safety must be monitored.

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