What is the mechanism of action of sildenafil in treating erectile dysfunction?

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Multiple Choice

What is the mechanism of action of sildenafil in treating erectile dysfunction?

Explanation:
Sildenafil works by inhibiting an enzyme called PDE5 in the penile tissue, which normally breaks down the signaling molecule cGMP. During sexual arousal, nitric oxide is released and stimulates production of cGMP, causing the smooth muscle around the penile arteries to relax. This relaxation allows more blood to flow into the corpora cavernosa, producing an erection. By blocking PDE5, sildenafil sustains higher cGMP levels, thus enhancing the natural NO-cGMP–mediated vasodilation that leads to erection. It relies on sexual stimulation to trigger NO release, so it does not cause an erection on its own.

Sildenafil works by inhibiting an enzyme called PDE5 in the penile tissue, which normally breaks down the signaling molecule cGMP. During sexual arousal, nitric oxide is released and stimulates production of cGMP, causing the smooth muscle around the penile arteries to relax. This relaxation allows more blood to flow into the corpora cavernosa, producing an erection. By blocking PDE5, sildenafil sustains higher cGMP levels, thus enhancing the natural NO-cGMP–mediated vasodilation that leads to erection. It relies on sexual stimulation to trigger NO release, so it does not cause an erection on its own.

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