Dopamine has what effect on prolactin release?

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Prepare for the Dr. High Yield Psychiatry Test. Study with flashcards and multiple choice questions, each with hints and explanations. Ensure success in your exam!

Multiple Choice

Dopamine has what effect on prolactin release?

Explanation:
Dopamine serves as the prolactin-inhibiting factor. It is released from neurons in the hypothalamus and travels to the anterior pituitary, where it binds to D2 receptors on lactotroph cells. This receptor activation dampens adenylyl cyclase activity, lowers cAMP, reduces calcium signaling, and thereby suppresses the exocytosis of prolactin-containing vesicles. The net effect is a decrease in prolactin release. Clinically, enhancing dopaminergic action reduces prolactin (as with dopamine agonists), whereas blocking dopamine receptors increases prolactin levels.

Dopamine serves as the prolactin-inhibiting factor. It is released from neurons in the hypothalamus and travels to the anterior pituitary, where it binds to D2 receptors on lactotroph cells. This receptor activation dampens adenylyl cyclase activity, lowers cAMP, reduces calcium signaling, and thereby suppresses the exocytosis of prolactin-containing vesicles. The net effect is a decrease in prolactin release. Clinically, enhancing dopaminergic action reduces prolactin (as with dopamine agonists), whereas blocking dopamine receptors increases prolactin levels.

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